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Quick Details

  • CAS No.: 224452-66-8
  • Other Names: retapamulin
  • MF: C30H47NO4S
  • EINECS No.: N/A
  • Place of Origin: Shaanxi, China (Mainland)
  • Type: Pharmaceutical Intermediates
  • Purity: 98.5%min
  • Brand Name: TOP
  • Model Number: TOP130201
  • Application: Pharmaceutical intermediates&antibiotics
  • Appearance: off-white powder

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Retapamulin
CAS 224452-66-8
M.F. C30H47NO4S

Usage: Antibiotics

Assay:98.5%

Retapamulin is a topical antibiotic developed by GlaxoSmithKline. It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use. It is marketed as an ointment under the brand names Altabax and Altargo.

Retapamulin was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo. In May 2007, retapamulin received approval in the EU from the European Medicines Agency for the same indication.

Clinical trials have demonstrated its efficacy against certain Gram-positive bacteria including MRSA.

Pharmacology

Mechanism of action

Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor. The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics.

Pharmakinetics

Systemic exposure following topical application through intact skin is low.

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