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Quick Details

  • CAS No.: 59865-13-3
  • Other Names: Antibiotic S 7481F1; Cyclosporine
  • MF: C62H111N11O12
  • Place of Origin: Shaanxi, China (Mainland)
  • Type: Auxiliaries and Other Medicinal Chemicals
  • Grade Standard: Medicine Grade
  • Brand Name: TOP-PHARM
  • Model Number: TOP-SF
  • Purity: 99.9% EP USP BP

Packaging & Delivery

Packaging Details: 25Kg/drum
Delivery Detail: 3days

Ciclosporin (INN/BAN) (pronounced /cyclosporine (USAN), cyclosporin (former BAN), or cyclosporin A is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity of T cells. Initially isolated from the fungus Tolypocladium inflatum isolated from a soil sample obtained by Sandoz scientists at Hardangervidda, Norway in 1969.[citation needed] Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.[2]

 

Ciclosporin

 
 
Systematic (IUPAC) name
(E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl) -1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30- undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone
Clinical data
Trade namesNeoral Sandimmune
AHFS/Drugs.commonograph
MedlinePlusa601207
Pregnancy cat.C (AU) C (US)
Legal statusPrescription Only (S4) (AU) POM (UK) -only (US)
Routesoral IVophthalmic
Pharmacokinetic data
Bioavailabilityvariable
Metabolismhepatic
Half-lifevariable (about 24 hours)
Excretionbiliary
Identifiers
CAS number59865-13-3 
ATC codeL04AD01 S01XA18
PubChemCID 5284373
DrugBankDB00091
ChemSpider4447449 Y
UNII83HN0GTJ6D Y
KEGGD00184 Y
ChEMBLCHEMBL160 Y
Chemical data
FormulaC62H111N11O12 
Mol. mass1202.61
InChI[show
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China (Mainland) | Manufacturer, Trading Company
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