Cyclosporin A 99.9% EP USP BP

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Overview
Quick Details
CAS No.:
59865-13-3
Other Names:
Antibiotic S 7481F1; Cyclosporine
MF:
C62H111N11O12
Place of Origin:
Shaanxi, China (Mainland)
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
TOP-PHARM
Model Number:
TOP-SF
Purity:
99.9% EP USP BP
Packaging & Delivery
Packaging Details
25Kg/drum
Port
China main ports
Lead Time :
3days

Ciclosporin (INN/BAN) (pronounced /cyclosporine (USAN), cyclosporin (former BAN), or cyclosporin A is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity of T cells. Initially isolated from the fungus Tolypocladium inflatum isolated from a soil sample obtained by Sandoz scientists at Hardangervidda, Norway in 1969.[citation needed] Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.[2]

 

Ciclosporin

 
 
Systematic (IUPAC) name
(E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl) -1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30- undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone
Clinical data
Trade namesNeoral Sandimmune
AHFS/Drugs.commonograph
MedlinePlusa601207
Pregnancy cat.C (AU) C (US)
Legal statusPrescription Only (S4) (AU) POM (UK) -only (US)
Routesoral IVophthalmic
Pharmacokinetic data
Bioavailabilityvariable
Metabolismhepatic
Half-lifevariable (about 24 hours)
Excretionbiliary
Identifiers
CAS number59865-13-3 
ATC codeL04AD01 S01XA18
PubChemCID 5284373
DrugBankDB00091
ChemSpider4447449 Y
UNII83HN0GTJ6D Y
KEGGD00184 Y
ChEMBLCHEMBL160 Y
Chemical data
FormulaC62H111N11O12 
Mol. mass1202.61
InChI[show