Main estrogens Estriol 50-27-1 Treating Multiple Sclerosis, Quality 99% Estriol

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Overview
Quick Details
CAS No.:
50-27-1
Other Names:
Estriol
MF:
C18H24O3
EINECS No.:
200-022-2
Place of Origin:
Shaanxi, China (Mainland)
Type:
Auxiliaries and Other Medicinal Chemicals, Endocrine System Agents, Urinary System Agents
Grade Standard:
Medicine Grade
Brand Name:
TOP-PHARMCHEM
Model Number:
TPAC
Purity:
99%
Appearance:
White or almost white, crystalline powder.
Solubility:
Practically insoluble in water, sparingly soluble in ethanol (96%).
Melting Point:
about 282 °C.
IDENTIFICATION1:
Infrared absorption spectrophotometry
IDENTIFICATION2:
Thin-layer chromatography
Specific optical rotation:
+ 60 to + 65 (dried substance).
Loss on drying:
Maximum 0.5 per cent
Impurity A:
not more than 0.5%
Sum of impurities other than A:
not more than 1.0%
Assay:
No Less than 99%
Packaging & Delivery
Packaging Details
1kg/bag or /Al can. it can be customised
Port
Any port of China
Lead Time :
1 days

Estriol

Let's start at the beginning: Three forms of estrogen occur naturally in a woman's body. The ovary produces a form named estradiol, which is converted into another important estrogen called estrone. Estriol is yet another form of estrogen metabolized from estradiol, weaker than the other two, but still active. Although estriol is most commonly linked to pregnancy since it is produced in the most measurable amounts at that time, it is still present throughout a woman's lifetime at varying levels and fluctuate throughout the day.

Because estriol has been considered a by-product of another from of estrogen and thus too weak to matter, it has been largely overlooked as a beneficial piece of the hormone pie. However, studies suggest that it can help reduce a variety of symptoms associated with perimenopause and menopause, including:

  • Hot flashes
  • Vaginal dryness
  • Bone density

In addition, research points to the benefits of estriol for heart health, post-menopausal urinary tract health and protection against osteoporosis.

Estriol's strength is actually found in its weakness. Tests show that while relieving the symptoms of perimenopause and menopause, estriol doesn't seem to increase the risk of breast cancer. This is because estriol binds to the estrogen receptors on the breast cells, but it has much weaker activity. Therefore, it actually blocks the stronger estradiol from binding to those cells and subjecting them to the higher estrogenic activity which has been shown to be protective against breast cancer. And for women who have difficulty tolerating stronger estrogens for the treatment of hormonal imbalance due to aging, estriol is often the right choice.

For women experiencing symptoms of perimenopause or menopause, your BodyLogicMD affiliated doctor may test your estriol levels.

 

ITEM

SPECIFICATION

RESULT

Character

White or almost white crystalline powder

White crystalline powder

Specific rotation

+54°to +62°

+59.9°

Completeness of solution

Clear and free from undissolved solid

Conforms

Identification

(1)    complies by IR

(2)    complies by UV

Conforms

Conforms

Residue on Ignition

Not more than 0.1%

0.04%

Loss on drying

Not more than 0.5

0.09%

Chromatographic purity

Total impurities not more than 2.0%

<2.0%

Assay

It should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis

99.30%

Particle size

It should be 90% below 30μm

Conforms

Conclusion

The goods conform to USP and customer standard

 

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